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Ring chromosome instability evaluation in six patients with autosomal rings
(Funpec-editora, 2010-01-01)
Ring chromosomes are often associated with abnormal phenotypes due to loss of genomic material and also because of ring instability at mitosis after sister chromatid exchange events. We investigated ring chromosome instability ...
Cytogenetic analysis of B chromosomes in one population of the fish Moenkhausia sanctaefilomenae (Steindachner, 1907) (Teleostei, Characiformes)
(Zoological Inst, 2012-01-01)
The aim of this study was to characterize cytogenetically one population of the fish Moenkhausia sanctaefilomenae (Steindachner, 1907), with emphasis on the analysis of B chromosomes. The nucleolar activity in the B ...
Telomere shortening, ageing, and chromosome damage
(Elsevier B.V., 1996-07-31)
A relationship between telomere shortening and ageing has been established. A series of young and elderly healthy donors, Alzheimer disease patients, young and old Down's syndrome individuals were cytogenetically analyzed. ...
Cell death evaluation in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17
(Elsevier B.V., 2004-02-26)
The incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated ...
Distinct regions of loss of heterozygosity on 22q at different sites of head and neck squamous cell carcinomas
(2002-04-10)
Background: Frequent loss of heterozygosity (LOH) has been reported in many types of cancer, including head and neck carcinomas. Somatic deletions involving specific chromosomal regions are strongly associated with ...
Cytogenetic and Molecular Evaluation and 20-Year Follow-Up of a Patient With Ring Chromosome 14
(Wiley-Blackwell, 2010-11-01)
We present a 20-year follow-up on a patient with a ring chromosome 14. the ring chromosome was studied by fluorescence in-situ hybridization (FISH), multiplex-ligation probe amplification (MLPA), and genome wide SNP array, ...
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
(Soc Brasil Genetica, 1995-09-01)
After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality ...
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions
(1999-03-01)
Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with ...
Chromosome polymorphism in the Brazilian dwarf brocket deer, Mazama nana (Mammalia, Cervidae)
(Sociedade Brasileira de Genética, 2008-01-01)
The Brazilian dwarf brocket deer (Mazama nana) is the smallest deer species in Brazil and is considered threatened due to the reduction and alteration of its habitat, the Atlantic Rainforest. Moreover, previous work suggested ...
Genetic alterations in benign lesions: Chronic gastritis and gastric ulcer
(2006-01-28)
Aim: To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori ...