Now showing items 1-10 of 132
Ceramide is a Mediator of Apoptosis in Retina Photoreceptors
(Association for Research in Vision and Ophthalmology, 2006-04)
PURPOSE. The precise mechanisms involved in photoreceptor apoptosis are still unclear. We here investigated the role of ceramide, a sphingolipid precursor that induces apoptosis upon cellular stress, in activating this ...
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
(ELSEVIER SCIENCE BV, 2008-01-15)
Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
Saturated Ceramides from the Sponge Dysidea robusta
(NATURAL PRODUCTS INC, 2009)
Chemical investigation of the crude extract of a marine sponge Dysidea robusta led to the isolation of an inseparable mixture of saturated ceramides. These were identified from spectroscopic data as well as by hydrolysis ...
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
N-Acyl Chain in Ceramide and Sphingomyelin Determines Their Mixing Behavior, Phase State, and Surface Topography in Langmuir Films
(American Chemical Society, 2014-06)
Sphingolipids are membrane lipids composed by a long chain aminediol base, usually sphingosine, with a N-linked fatty acyl chain whose quality depends on the membrane type. The effect of length and unsaturation of the ...
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
(ELSEVIER SCIENCE INC, 2008-03-15)
In lymphocytes, Fas activation leads to both apoptosis and necrosis, whereby the latter form of cell death is linked to delayed production of endogenous ceramide and is mimicked by exogenous administration of long- and ...
Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel
(Archives of Biochemistry and Biophysics, 2013)
Hexagonal phase with ordered acyl chains formed by a short chain asymmetric ceramide
(Elsevier Science, 2017-01)
Ceramides constitute a group of lipids with usually high melting temperature that also favor negative curvature in membranes when mixed with other lipids. The short chain C10:0 ceramide is an asymmetric lipid which consists ...
Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis
(Elsevier Science, 2014-01)
Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain ...
Changes in ceramide metabolism are essential in Madin-Darby canine kidney cell differentiation
(American Society for Biochemistry and Molecular Biology, 2017-07)
Ceramides and complex sphingolipids with defined acyl-chain lengths play important roles in numerous cell processes. Six ceramide synthase isoenzymes (CerS1-6) are the key enzymes responsible for the production of the ...