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Synthesis and cytotoxicity of a ruthenium nitrosyl nitric oxide donor with isonicotinic acid and a cell penetrating peptide
(2013-02-01)
The syntheses and properties of trans-[Ru(NH3) 4(L)(NO)](BF4)3 (L = isonicotinic acid (inaH) (I) or ina-Tat48-60 (II)) are described. Tat48-60, a cell penetrating peptide fragment of the Tat regulatory protein of the HIV ...
The Natural Cell-Penetrating Peptide Crotamine Targets Tumor Tissue in Vivo and Triggers a Lethal Calcium-Dependent Pathway in Cultured Cells
(AMER CHEMICAL SOCWASHINGTON, 2012)
Our goal was to demonstrate the in vivo tumor specific accumulation of crotamine, a natural peptide from the venom of the South American rattlesnake Crotalus durissus terrificus, which has been characterized by our group ...
Insulin-loaded liposomes functionalized with cell-penetrating peptides: influence on drug release and permeation through porcine nasal mucosa
(2021-08-05)
The nasal route is promising for the delivery of insulin for diabetes treatment. Drug loading into delivery systems such as liposomes can improve the bioavailability of insulin for this route. Herein, we address the ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(Elsevier Ireland, 2017-10)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(Elsevier B.V., 2017-10-01)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(2017-10-01)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...
Oligoarginine peptide conjugated to BSA improves cell penetration of gold nanorods and nanoprisms for biomedical applications
(MDPI, 2021)
Gold nanoparticles (AuNPs) have been shown to be outstanding tools for drug delivery and biomedical applications, mainly owing to their colloidal stability, surface chemistry, and
photothermal properties. The biocompatibility ...
Crotamine toxicity and efficacy in mouse models of melanoma
(INFORMA HEALTHCARE, 2011)
Objectives: Selective anticancer cell activity for both cell-penetrating and cationic antimicrobial peptides has previously been reported. As crotamine possesses activities similar to both of these, this study investigates ...
TAT-mediated transduction of bacterial redox proteins generates a cytoprotective effect on neuronal cells
(Public Library of Science, 2017-09)
Cell penetrating peptides, also known as protein transduction domains, have the capacity to ubiquitously cross cellular membranes carrying many different cargos with negligible cytotoxicity. As a result, they have emerged ...
Membrane-translocating peptides and toxins: from nature to bedside
(Sociedade Brasileira de Química, 2008-01-01)
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or ...