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DNA methylation analysis of the tumor suppressor gene CDKN2B in Brazilian leukemia patients
(Sociedade Brasileira de Genética, 2008)
The aim of this work was to evaluate the methylation profile of the p15 (CDKN2B) gene in Brazilian patients with leukemia and to correlate the CDKN2B gene expression with the percentage of methylated CpG dinucleotides in ...
Genome-wide DNA methylation profile of leukocytes from melanoma patients with and without CDKN2A mutations
(Elsevier Inc.Maryland Heights, 2014-12)
Melanoma is a highly aggressive cancer, accounting for up to 75% of skin cancer deaths. A small proportion of melanoma cases can be ascribed to the presence of highly penetrant germline mutations, and approximately 40% of ...
Inactivación del gen CDKN2A (p16) en cáncer de la vesícula biliar
(Sociedad Médica de Santiago, 2004)
CDKN2A promoter hypermethylation in astrocytomas is associated with age and sex
(2013-06-12)
CDKN2A promoter hypermethylation has been widely related to many cancers. In astrocytomas, although CDKN2A (p16INK4A protein) is often inactivated, there are still some controversial issues regarding the mechanism by which ...
Polymorphisms of CDKN1A gene and risk of retinoblastoma
(Oxford University Press, 2016)
Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer
(Associação Brasileira de Divulgação Científica, 2008)
Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide. DNA methylation is the most studied epigenetic alteration, occurring through a methyl radical addition to the ...
Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma
(Spandidos Publ Ltd, 2016)
Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ...
Estudio molecular de los genes CDKN1B y CITED2 en mujeres con falla ovárica prematura idiopática
(Universidad del RosarioMaestría en Ciencias con Énfasis en Genética HumanaFacultad de medicina, 2011)