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The 3D structure and function of digestive cathepsin L-like proteinases of Tenebrio molitor larval midgut
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Cathepsin L-like proteinases (CAL) are major digestive proteinases in the beetle Tenebrio molitor. Procathepsin Ls 2 (pCAL2) and 3 (pCAL3) were expressed as recombinant proteins in Escherichia coil, purified and activated ...
Characterization of thiol-, aspartyl-, and thiol-metallo-peptidase activities in Madin-Darby canine kidney cells
(Wiley-Blackwell, 2000-01-01)
We combined fluorogenic substrates or internally quenched fluorescent peptides with specific inhibitors in the pH profile of proleolytic activity experiments in order to detect proteolytic activities in lysates of MDCK ...
The highly antigenic 53/25kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs
(Elsevier, 2012)
Cathepsin L-like proteases are secreted by several parasites including Taenia solium. The mechanism used by T. solium oncospheres to degrade and penetrate the intestine and infect the host is incompletely understood. It ...
Temporal Changes in Matrix Metalloproteinases, Their Inhibitors, and Cathepsins in Mouse Pubic Symphysis During Pregnancy and Postpartum
(Sage Publications IncThousand OaksEUA, 2011)
Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity
(Elsevier B.V., 2001-09-03)
We have isolated and purified two cysteine proteinases of molecular weights 25 and 26 kDa, secreted by Fasciola hepatica adult worm. Their 15 N-terminal residues were found to be identical to those of earlier described ...
Cathepsin L3 from fasciola hepatica induces NLRP3 inflammasome alternative activation in murine dendritic cells
(Frontiers Media S.A., 2019-03)
The production of IL-1-family cytokines such as IL-1β and IL-18 is finely regulated by inflammasome activation after the recognition of pathogens associated molecular pattern (PAMPs) and danger associated molecular patterns ...
Biologia molecular aplicada à identificação de alvos para o controle do bicudo da cana-de-açucar, Sphenophorus levis
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2012-02-29)
The sugarcane weevil, Sphenophorus levis, is an insect that feeds on the rhizome of sugarcane in its larval stage, boring channels that cause damage and death to the plant. Conventional methods of insect control have not ...
Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-Oxide derivatives
(MDPI, 2019)
Infections caused by Fasciola species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in ...