Now showing items 1-10 of 204
A fragment-based approach for the in silico prediction of blood-brain barrier permeation
(Sociedade Brasileira de Química, 2012)
Blood-brain barrier (BBB) permeation is an essential property for drugs that act in the central nervous system (CNS) for the treatment of human diseases, such as epilepsy, depression, Alzheimer's disease, Parkinson disease, ...
The serine protease homolog, scarface, is sensitive to nutrient availability and modulates the development of the drosophila blood brain barrier
(Soc. Neuroscience, 2021)
The adaptable transcriptional response to changes in food availability not only ensures animal survival but also lets embryonic development progress. Interestingly, the CNS is preferentially protected from periods of ...
Blood-brain barrier breakdown following gliotoxic drug injection in the brainstern of Wistar rats
(Assoc Arquivos De Neuro- PsiquiatriaSao Paulo SpBrasil, 2002)
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014-01-01)
The treatment of central nervous system (CNS) diseases is a major challenge. The presence of the barrier intended to protect the brain from unwanted molecules also impairs the efficacy of CNS-targeted drugs. The discovery ...
Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation
Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that involves damage to the myelin sheath surrounding axons. MS therapy is based on immunomodulatory drugs that reduce disease recurrence ...
High performance collection of cerebrospinal fluid in rats: evaluation of erythropoietin penetration after osmotic opening of the blood-brain barrier
An important issue to be considered when studying a new drug for treatment of central nervous system (CNS) diseases is its ability to cross the blood–brain barrier (BBB) and distribute throughout the brain. As cerebrospinal ...
Effect of monocrotaline on blood brain barrier permeability in rats
(Colegio Farmaceuticos Provincia de Buenos Aires, 2011-02)
We studied if monocrotaline (MCT) portal hypertensive model modiies blood-brain barrier (BBB) condition. Male Wistar rats were used: Group MCT i.p. with MCT (60 mg/Kg of body weight) and Group Sham (GS) with saline. ...