Now showing items 1-10 of 139
Validation of an HPLC Method for quantitative Determination of Benzocaine in PHBV-Microparticles and PLA-Nanoparticles
(Colegio Farmaceuticos Provincia de Buenos Aires, 2009-05-01)
Benzocaine (BZC) is an ester-type local anesthetic used mainly in topical, dermal and mucosal formulations. The present work consists of the development and validation of analytical methodology for evaluation of benzocaine ...
Benzocaine loaded biodegradable poly-(D,L-lactide-co-glycolide) nanocapsules: factorial design and characterization
(Elsevier B.V., 2009-12-15)
Local anesthetics are able to induce pain relief since they bind to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nervous impulse. Benzocaine (BZC) is a local ...
Thermodynamic study of benzocaine insertion into different lipid bilayers
(American Institute of Physics, 2011-10)
Despite the general consensus concerning the role played by sodium channels in the molecular mechanism of local anesthetics, the potency of anaesthetic drugs also seems to be related with their solubility in lipid bilayers. ...
Anesthesia of fish with benzocaine does not interfere with comet assay results
Fish blood erythrocytes are frequently used as sentinels in biomonitoring studies. Usually, fish blood is collected by painful cardiac or caudal vein punctures. Previous anesthesia could decrease animal suffering but it ...
Poly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activity
(Springer/plenum Publishers, 2011-08-01)
The aim of this work was to investigate the influence of the oily nucleus composition on physico-chemical properties and anesthetic activity of poly (lactide-co-glycolide) nanocapsules with benzocaine.Nanocapsules containing ...
Efficacy of 1% ropivacaine gel for topical anesthesia of human oral mucosa
(Quintessence Publishing Co IncHanover ParkEUA, 2007)
Benzocaine-loaded polymeric nanocapsules: Study of the anesthetic activities
This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(d,l-lactide-co-glycolide), poly(l-lactide) (PLA), and poly(e-caprolactone) and used as carrier systems for the ...
Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia
(Elsevier Science IncNew YorkEUA, 2010)