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Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Novel bisbenzimidazoles (4-6), characterized by 3,4-ethylenedioxy-extension of thiophene core, revealed pronounced affinity and strong thermal stabilization effect toward ds-DNA. They interact within ds-DNA grooves as ...
Direct thrombin inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in people with non-valvular atrial fibrillation
(Wiley, 2014)
BACKGROUND: Chronic anticoagulation with vitamin K antagonists (VKAs) prevents ischaemic stroke and systemic embolism in people with non-valvular atrial fibrillation (AF) but dose adjustment, coagulation monitoring and ...
Síntese e estrutura de compostos poliaza heterocíclicos
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2012-07-27)
This work describes the synthesis of a number of polyaza heterocycles and
the mechanistic study to obtain these products. Furthermore, the characterization
was performed by spectroscopic method and the structural study by ...