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Kinase-Impaired BRAF Mutations in Lung Cancer Confer Sensitivity to Dasatinib
(AMER ASSOC ADVANCEMENT SCIENCE, 2012)
During a clinical trial of the tyrosine kinase inhibitor dasatinib for advanced non-small cell lung cancer (NSCLC), one patient responded dramatically and remains cancer-free 4 years later. A comprehensive analysis of his ...
Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
(NATURE PUBLISHING GROUP, 2006)
The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase signaling pathway can be activated through mutations of V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) oncogene, frequently found in ...
AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma
(Wiley-Blackwell, 2016)
Thyroid cancer is the fastest increasing cancer worldwide in all age groups. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer in both adults and children. PTC genomic landscape has been extensively ...
High Prevalence of BRAF Mutation in a Brazilian Cohort of Patients With Sporadic Papillary Thyroid Carcinomas Correlation With More Aggressive Phenotype and Decreased Expression of Iodide-Metabolizing Genes
(Wiley-Blackwell, 2009-03-01)
BACKGROUND: Although several studies undoubtedly demonstrated that BRAF mutation is an important genetic event in the pathogenesis of papillary thyroid carcinoma (PTC), its prognostic significance and correlation with less ...
Characterization of the B-Raf interactome in mouse hippocampal neuronal cells
(Elsevier Science, 2011-02)
B-Raf links a variety of extracellular stimuli downstream of cell surface receptors, constituting a determining factor in the ability of neurons to activate ERK. A detailed study of the B-Raf interactome is necessary to ...
Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
(2013)
Numerous experiments have been conducted over the last few years aiming to identify molecular markers that show the diagnostic accuracy of fine‑needle aspiration (FNA), particularly in thyroid lesions that are considered ...
Avaliação da heterogeneidade intratumoral e intermetástases do éxon 15 do gene braf (7q34) em amostras de melanoma metastático
(Universidade Federal de São Paulo (UNIFESP), 2015-06-05)
Introduction: Approximately a half of cutaneous melanoma has a BRAF V600E mutation and benefits from treatment with BRAF and MEK inhibitors, showing rapid tumor regression. However, most of these patients had progression ...
Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-11-01)
BACKGROUND: Recent studies reported that BRAF V600E mutation, the most prevalent genetic event found in papillary thyroid carcinoma, is an independent poor prognostic marker. Additionally, it correlates with a less ...