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Niemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice
(SPRINGER HEIDELBERG, 2012)
Niemann-Pick C2 protein (NPC2) is a lysosomal soluble protein that is highly expressed in the liver; it binds to cholesterol and is involved in intracellular cholesterol trafficking, allowing the exit of lysosomal cholesterol ...
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1999)
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration. Cholesterol and sphingomyelin ...
Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003)
We examined in vivo a role for sterol carrier protein-2 (SCP-2) in the regulation of lipid secretion across the hepatic sinusoidal and canalicular membranes. Recombinant adenovirus Ad.rSCP2 was used to overexpress SCP-2 ...
Apolipoprotein a-i deficiency does not affect biliary lipid secretion and gallstone formation in mice
(WILEY-BLACKWELL PUBLISHING, INC, 2011)
Apolipoprotein a-i deficiency does not affect biliary lipid secretion and gallstone formation in mice
(BLACKWELL MUNKSGAARD, 2011)
Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice
(WILEY, 2002)
Receptor-mediated endocytosis is one of the major mechanisms for uptake of lipoprotein cholesterol in the liver. Because Niemann-Pick C1 (NPC1) protein is a key component in the intracellular distribution of cholesterol ...