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Development of Conformation Independent Computational Models for the Early Recognition of Breast Cancer Resistance Protein substrates
(Hindawi Publishing Corporation, 2013-06)
ATP-Binding Cassette (ABC) efflux transporters are polyspecific members of the ABC superfamily that, acting as drug and metabolite carriers, provide a biochemical barrier against drug penetration and contribute to ...
Integrated application of enhanced replacement method and ensemble learning for the prediction of BCRP/ABCG2 substrates
(Bentham Science Publishers, 2017-06)
Background: Breast Cancer Resistance Protein (BCRP or ABCG2) is a polyspecific efflux transporter which belongs to the ATP-binding Cassette superfamily. Up-regulation of BCRP is associated to multi-drug resistance in a ...
The phytoestrogens daidzein and equol inhibit the drug transporter BCRP/ABCG2 in breast cancer cells: potential chemosensitizing effect
(Dr Dietrich Steinkopff Verlag, 2017-11)
PURPOSE: The soy isoflavone genistein has been described to up-regulate breast cancer resistance protein (BCRP) and, thus, enhance chemoresistance in breast cancer cells. The aim of this work was to assess the effect of ...
Development and Validation of a Computational Model Ensemble for the Early Detection of BCRP/ABCG2 Substrates during the Drug Design Stage
(American Chemical Society, 2017-08)
Breast Cancer Resistance Protein (BCRP) is an ATP-dependent efflux transporter linked to the multidrug resistance phenomenon in many diseases such as epilepsy and cancer and a potential source of drug interactions. For ...
Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions
P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are ATP binding cassette (ABC) transporters that are overexpressed in different drug-resistant cancer cell lines. In this study, we investigated whether ...
Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier
(Elsevier Science, 2017-10)
Treatment of retinoblastoma -a pediatric cancer of the developing retina- might benefit from strategies to inhibit the blood-retinal barrier (BRB). The potent anticancer agent topotecan is a substrate of efflux transporters ...
Intestinal drug transport: ex vivo evaluation of the interactions between ABC transporters and anthelmintic molecules
(Wiley, 2014-03)
The family of ATP-binding cassette (ABC) transporters is composed of several transmembrane proteins that are involved in the efflux of a large number of drugs including ivermectin, a macrocyclic lactone (ML) endectocide, ...