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Clinicopathological significance of ERCC1 expression in breast cancer
(2013-06-01)
The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway and is associated with resistance to platinum-based chemotherapy in different types of cancer. ...
DNA repair kinetic of hydrogen peroxide and UVA/B induced lesions in peripheral blood leucocytes from xeroderma pigmentosum patients and healthy subjects
(Begell House Inc, 2014-11)
The objective of the present work was to study the fine kinetics of DNA repair in xeroderma pigmentosum (XP) syndrome, a complex disorder linked to a deficiency in repair that increases cancer susceptibility. The repair ...
Genetic variability and DNA repair: base excision repair activities in Helicobacter pylori .
(American Scientific Publishers, 2003-03)
One of the remarkable characteristics of Helicobacter pylori is the high genetic diversity it displays. Based on the genome sequencing results, the absence of certain DNA repair activities has been postulated to be one of ...
Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes
(Wiley-Blackwell, 2014-07-01)
Problem The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1). We investigated OGG1 expression changes in ...
Epigenetic Regulation Of Dna Repair Machinery In Helicobacter Pylori-induced Gastric Carcinogenesis
(BAISHIDENG PUBLISHING GROUP INCPLEASANTON, 2015)
Base Excision Repair Activities Differ in Human Lung Cancer Cells and Corresponding Normal Controls
(INT INST ANTICANCER RESEARCH, 2010)
Oxidative damage to DNA is thought to play a role in carcinogenesis by causing Mutations, and indeed accumulation of oxidized DNA bases has been observed in samples obtained from tumors but not from surrounding tissue ...
Accumulation of (5 ` S)-8,5 `-cyclo-2 `-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
(ELSEVIER SCIENCE BV, 2009)
Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementation group B (CS-B) gene (csb) encodes the CSB protein ...