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Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy
(2021-01-15)
Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-resistance by tumor cells represents a primary obstacle for successful chemotherapy. Autophagy is a physiological mechanism of ...
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins
(Landes Bioscience, 2015-12)
Autophagy is activated early after human cytomegalovirus (HCMV) infection, but lateron the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 andIRS1, which inhibit autophagy during infection. Expression ...
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity
(Elsevier, 2016)
Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
Moderate, but not excessive, training attenuates autophagy machinery in metabolic tissues
(2020-11-02)
The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, ...
Autophagy: friend or foe in breast cancer development, progression and treatment
(Hindawi Publishing Corporation, 2011-06)
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some ...
Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
(2016)
Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity
(Taylor & Francis, 2013-07)
Autophagy is a cell process that in normal conditions serves to recycle cytoplasmic components and aged or damaged organelles. The autophagic pathway has been implicated in many physiological and pathological situations, ...
PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy
(Wiley-liss, Div John Wiley & Sons Inc, 2016-03)
Protein kinase C (PKC) is a family of serine/threonine kinases that regulate diverse cellular functions including cell death, proliferation, and survival. Recent studies have reported that PKCδ, are involved in apoptosis ...