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The kaleidoscope of autoimmunity: Multiple autoimmune syndromes and familial autoimmunity
Three related lines of evidence sustain the common origin for autoimmune diseases (ADs). First, the clinical evidence corresponding to the kaleidoscope of autoimmunity, which is the co-occurrence of various ADs within an ...
Autoimmunity and autoimmune disease: A Colombian construction beyond deconstructions
The first Colombian Autoimmune Symposium held in Medellin, Colombia, February 23–25, 2005, covered the entire spectrum of the diverse aspects of autoimmunity and autoimmune disorders. The symposium originated as part of a ...
The autoimmune tautology: From polyautoimmunity and familial autoimmunity to the autoimmune genes.
Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens and represent a heterogeneous group of disorders that afflict specific target organs or multiple organ ...
The Autoimmune Tautology: From Polyautoimmunity and Familial Autoimmunity to the Autoimmune Genes
(Universidad del Rosario, 2012)
Autoimmune diseases (ADs) are chronic conditions initiated
by the loss of immunological tolerance to self-antigens and
represent a heterogeneous group of disorders that afflict specific
target organs ormultiple organ ...
Autoimmune disease aggregation in families with primary Sjögren's syndrome
Objective. Diverse autoimmune diseases may coexist in the same individual and in families, implying a common etiology. We examined the aggregation of autoimmune diseases among first-degree relatives (FDR) of patients with ...
How do autoimmune diseases cluster in families? A systematic review and meta-analysis
(Universidad del Rosario, 2013)
Background: A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as ...
Common mechanisms of autoimmune diseases (the autoimmune tautology)
The fact that autoimmune diseases share subphenotypes, physiopathological mechanisms and genetic factors has been called autoimmune tautology, and indicates that they have a common origin. The autoimmune phenotypes vary ...
Polyautoimmunity and familial autoimmunity in systemic sclerosis
Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this ...
Facts and challenges for the autoimmunologist. Lessons from the second Colombian autoimmune symposium
The first Colombian Autoimmune Symposium took place in Medellin in February 2005 [1]. Since then, much progress has been made. Among others, two facts have marked the recent history of the field of autoimmunity. The first ...
Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
Similar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When ...