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Mostrando ítems 1-10 de 21
MPO Inhibitors Selected by Virtual Screening
(WILEY-BLACKWELL, 2011)
The hemeprotein myeloperoxidase (MPO) participates in innate immune defense through its ability to generate potent microbicidal oxidants. However, these oxidants are also key mediators of the tissue damage associated with ...
Novel green and more efficient reaction for the synthesis of aromatic hydrazides
(Sociedade Brasileira de Química, 2022)
Development of new lanthanide-based sensors depends on the rational design of ligands containing multiple
coordination sites and planar π-delocalized systems for light reception.[1] In this work we present a novel,
one-step ...
Síntese, análise estrutural e avaliação do potencial inibitório frente à enzima tirosinase por complexos de oxidovánadio(IV) e dioxidovanádio(V) derivados de hidrazidas aromáticas.
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2021-10-07)
Ten ligands were synthesized through aldol condensation of salicylic aldehyde and pyridoxal hydrochloride (C1AS, C2AS, C3AS, C4AS, C5AS, C1P, C2P, C3P, C4P and C5P) with five primary amines from p-substituted aromatic ...
Atividade catalítica promíscua de complexos imínicos derivados de hidrazidas e aldeídos aromáticos e suas respectivas atividades anti-biofilmes
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2022-11-03)
The work deals with the synthesis of new complexes of cations of first transition metal
series such as CoII, FeII, MnII and ZnII, from ligands derived from aromatic hydrazides
substituted with aromatic aldehydes ...
Síntese, análise estrutural e avaliação mimética da atividade catalítica da superóxido dismutase de complexos de cobre derivados de hidrazidas aromáticas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2018-08-03)
This work presents the synthesis, characterization of copper (II) complexes and the
potential of these compounds to mimic the catalytic activity of the enzyme superoxide
dismutase.
The complexes were obtained from the ...
Síntese de (5-trifluormetil-1H-pirazol-1-IL)(quinolin-4-IL)metanonas de interesse farmacológico
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2016-07-22)
A convergent synthesis of a series of 16 new polysubstituted (5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(quinolin-4-yl)methanones, starting from isatin and alky(aryl/heteroaryl) ketones, is described. The ...
Síntese, análise estrutural e avaliação da atividade inibitória da enzima urease por oxidovanádio (IV) e dioxidovanádio (V) complexos derivados de hidrazidas aromáticas
(Universidade Federal de Santa MariaBrasilUFSMCentro de Ciências Naturais e Exatas, 2019-07-05)
This work presents the synthesis and characterization of vanadium complexes and the potential of these compounds to inhibit the enzyme urease. The complexes were obtained from the aldol condensation between substituted ...
Síntese de BIS-1H-pirazóis trialometil substituídos
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2008-10-03)
The present research describes the use of b-alcoxyvinyl trihalomethyl ketones
(1,2) [CX3C(O)CHCRR1, where X: Cl, F; R: H, Me, Ph, 4-MePh, 4-MeOPh, 4-FPh, 4-
ClPh, 4-BrPh, 4-NO2Ph, 4,4 -Biphenyl, 1-Naphtyl, 2-Furyl, 2- ...