Now showing items 1-10 of 86
Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score
For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction ...
Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothı́rops snake venoms
A monospecific Bothrops lanceolatus antivenom, currently used in Martinique, was tested for its efficacy in the neutralization of several toxic and enzymatic activities of the venoms of B. lanceolatus, B. atrox and B. ...
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)
Neutralization of biological activities of B. asper myotoxin by a monospecific anti-myotoxin rabbit serum and polyvalent antivenom was studied. Both antisera neutralized myotoxic, phospholipase A and lethal activities of ...
Turbidity of hyperimmune equine antivenom: the role of phenol and serum lipoproteins
Twenty batches of polyvalent antivenom produced at the Instituto Clodomiro Picado were analyzed for turbidity, both before and after freezing-thawing and lyophilization. Eight batches became turbid upon freezing-thawing, ...
Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture
This study screened 25 sera, 19 synthetic products and five antivenoms obtained after immunization for their ability to neutralize the hemorrhagic activity of venom from the snake Bothrops asper. Among the sera screened, ...
An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica
The ability of several batches of polyvalent antivenom to neutralize indirect hemolytic activity of Bothrops asper venom was studied using a sensitive plate test. All samples of antivenom tested effectively neutralized ...