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Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds
(2016-04-01)
In the last decades, the increased number of immunocompromised patients has led to the emergence of many forms of fungal infections. Furthermore, there are a restricted arsenal of antifungals available and an increase in ...
Antifungal therapy: New advances in the understanding and treatment of mycosis
(2017-01-23)
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is ...
Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii
(2017-01-04)
Ethnopharmacological relevance Vismia guianensis (Aubl.) Pers. is traditionally used in North and Northeast of Brazil for the treatment of dermatomycoses. Since the strategy associating immunomodulators with antifungal ...
Brazilian copaifera species: Antifungal activity against clinically relevant candida species, cellular target, and in vivo toxicity
(2020-09-01)
Plants belonging to the genus Copaifera are widely used in Brazil due to their antimicrobial properties, among others. The re-emergence of classic fungal diseases as a consequence of antifungal resistance to available drugs ...
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity
(2018-08-25)
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, ...
Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals
(2022-03-01)
Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering ...
Antifungal activity in vitro and in vivo of extracts and lignans isolated from Larrea divaricata Cav. against phytopathogenic fungus
(Elsevier, 2013-03)
The aim of this study was to evaluate the effectiveness of organic extracts and isolated compounds of the medicinal plant Larrea divaricata Cav. against phytopathogenic fungi. Chloroformic extract showed the highest ...
In vitro antifungal susceptibility, in vivo antifungal activity and security from a natural product obtained from sunrise oil (AMO 3) against dermatophytes Actividad antifúngica y perfil de seguridad del producto natural derivado del aceite de maravilla o
(2011)
This work studied safety and antifungal activity of ozonized sunflower oil (AMO 3) against dermatophytes. AMO 3 was prepared through a new original process that modifies the oil before ozonation by alcoholic catalytic ...