The use of antidepressant in depressive illness results in a reduction of suicidal attempts and deaths due to suicide, conditions that are generally present in this disorder. Recently, the Federal Drug Administration (FDA) ...

The antinociceptive activity of the antidepressant agents imipramine, maprotiline and amitriptyline and their interactions with morphine and aminophylline were evaluated using the acetic acid writhing test of mouse. All ...

Background: Data from the Mnistry of Health show that in Chile in 2004, 17% of the population had some form of depresdon and mood disorders are the tenth cause of disability-adjusted life years (DALY) loss. Aim: To determine ...

The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, ...

Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed ...

When assessing a patient with depression it is crucial not to miss a diagnosis of bipolar depression. In this review we suggest that it can be achieved, first, by consistently using standardised diagnostic criteria (e.g. ...

Objectives. The primary aim of these guidelines was to evaluate the role of pharmacological agents in the treatment and management of paraphilia, with a focus on the treatment of adults males. Because such treatments are ...

Agmatine is the product of the decarboxylation of L-arginine by the enzyme arginine decarboxylase. This amine has been attributed to neurotransmitter functions, anticonvulsant, antineurotoxic, and antidepressant in mammals ...