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Planejamento racional por modelagem molecular, síntese e caracterização de glicosídeos com atividade inibitória potencial da acetilcolinesterase
(Universidade Federal de Minas GeraisUFMG, 2012-02-29)
Acetylcholinesterase (AChE) is the enzyme that catalyses the hydrolysis of the neurotransmitter acetylcholine, terminating synaptic cholinergic transmission. The use of AChE inhibitors have been associated with the improvement ...
CONSTRUCAO, OTIMIZACAO E ANCORAGEM MOLECULAR DE SUBSTANCIAS BIOATIVAS EM BIOMACROMOLECULAS: UM TUTORIAL PRATICO
(Soc Brasileira Quimica, 2021-09-15)
CONSTRUCTION, OPTIMIZATION AND MOLECULAR DOCKING OF BIOACTIVE SUBSTANCES IN BIOMACROMOLECULES: A PRACTICAL TUTORIAL. In the last two decades, increasing advances in molecular biology and instrumental analysis for solving ...
Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2018)
Síntese, ensaios in vitro e estudos computacionais de aminoquinolinas possíveis inibidoras da cruzaína e rodesaína
(Universidade Federal de Minas GeraisUFMG, 2016-02-24)
In this work a series of aminoquinolines, potential inhibitors of cruzain and rhodesain, was synthesized, evaluated on in vitro assays and studied by in silico methods. Chagas disease is caused by Tripanossoma cruzi and ...