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Insight into the effect of the vasopressin analog desmopressin on lung colonization by mammary carcinoma cells in BALB/c mice
(Int Inst Anticancer Research, 2014-07)
Background/Aim: Desmopressin (dDAVP) is a synthetic peptide analog of vasopressin with antidiuretic and hemostatic properties. Recent experimental evidence suggested that dDAVP can inhibit metastasis formation by agonist ...
1α,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo
(Endocrine Society, 2010-01)
The Kaposi sarcoma-associated herpes virus-G protein-coupled receptor is a key molecule in the pathogenesis of Kaposi sarcoma, playing a central role in promoting vascular endothelial growth factor-driven angiogenesis and ...
High performance voltage follower with very low output resistance for WTA applications
(Institute of Electronics, Information and Communication Engineers, 2016)
High performance voltage follower with very low output resistance for WTA applications
(Institute of Electronics, Information and Communication Engineers, 2016)
Synthesis of a novel analog of calcitriol and its biological evaluation as antitumor agent
(Pergamon-Elsevier Science Ltd, 2019-01-17)
Calcitriol analogs have shown promising potential as compounds to be used in cancer chemotherapy. This report presents the synthesis of a novel vitamin D3 derivative with an amide and a carboxyl group in its side chain, ...
Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs
(Springer, 2011-04)
Doxorubicin is an anti-tumor antibiotic widely used in the management of cancer patients. Its main mechanism of action involves the generation of DNA damage and the inhibition of topoisomerase II, promoting apoptosis. AD ...
Search of vasopressin analogs with antiproliferative activity on small-cell lung cancer: Drug design based on two different approaches
(Future Medicine, 2018-04)
Aim: Development of compounds with therapeutic application requires the interaction of different disciplines. Several tumors express vasopressin (AVP; arginine vasopressin) receptors with contrasting effects depending on ...
Development and therapeutic potential of vasopressin synthetic analog [V4Q5]dDAVP as a novel anticancer agent
(Elsevier Academic Press Inc., 2020-01)
Since its discovery, arginine vasopressin (AVP) was subjected to several modifications with the aim of obtaining novel derivatives with increased potency and selectivity for biomedical use. Desmopressin (dDAVP) is a first ...
Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model
(Springer, 2013-10)
Desmopressin (DDAVP), a synthetic peptide analog of vasopressin, is a safe antidiuretic and hemostatic compound that acts as a selective agonist for the vasopressin V2 membrane receptor. It is known that DDAVP can inhibit ...