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Amyloid Precursor Protein in Central and Peripheral Cholinergic Synaptopathies
(Nova Science Publishers, 2011-05)
Alzheimer´s disease is the most widespread form of dementia in the elderly. One of the characteristics of this disease is the profound functional deficit of the cholinergic system as a consequence of synaptic loss. Amyloid ...
Proinflammatory stimuli are needed for induction of microglial cell-mediated A beta PP244-C and A beta-neurotoxicity in hippocampal cultures
(IOS PRESS, 2008)
Amyloid-beta plaques and neurodegeneration are hallmarks of Alzheimer's disease, where glial cells are responsible for sustained neuroinflammation. Here we show that hippocampal-microglia co-cultures exposed to proinflammatory ...
Characterization of the beta amyloid precursor protein-like gene in the central nervous system of the crab Chasmagnathus. Expression during memory consolidation
(BioMed Central, 2010-09)
Background: Human β-amyloid, the main component in the neuritic plaques found in patients with Alzheimer's disease, is generated by cleavage of the β-amyloid precursor protein. Beyond the role in pathology, members of this ...
Adaptor protein 2-mediated endocytosis of the beta-secretase bace1 is dispensable for amyloid precursor protein processing
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)