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Time to rehospitalization in patients with schizophrenia discharged on first generation antipsychotics, non-clozapine second generation antipsychotics, or clozapine
(ELSEVIER IRELAND LTD, 2011)
Rehospitalization is an important outcome of drug effectiveness in schizophrenia. In this study, the hypothesis that clozapine and some second generation antipsychotics (SGA) were superior to first generation antipsychotics ...
Efeitos dos neurolépticos atípicos ziprasidona e amisulprida em modelos animais de discinesia tardia
(Universidade Federal de São Paulo (UNIFESP), 2009-01-01)
Tardive dyskinesia - the main side effect of long-term treatment with typical neuroleptics - has been related to nigrostriatal dopaminergic supersensitivity. Treatment with atypical neuroleptics is associated with a decreased ...
Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review
(Dove Press Limited, 2017)
Since the discovery of chlorpromazine (CPZ) in 1952, first-generation antipsychotics (FGAs) have revolutionized psychiatric care in terms of facilitating discharge from hospital and enabling large numbers of patients with ...
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?
(Oxford Univ Press, 2009-07-01)
Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal ...
Efficacy and safety of atypical antipsychotic drugs (quetiapine, risperidone, aripiprazole and paliperidone) compared with placebo or typical antipsychotic drugs for treating refractory schizophrenia: overview of systematic reviews
(Associação Paulista de Medicina - APM, 2010-05-01)
CONTEXT AND OBJECTIVE: According to some cohort studies, the prevalence of refractory schizophrenia (RS) is 20-40%. Our aim was to evaluate the effectiveness and safety of aripiprazole, paliperidone, quetiapine and risperidone ...
Cambios de las dinámicas de estados cerebrales durante modulación dopaminérgica en humanos
(Universidad de Chile, 2022)
Los estudios de neuroimaginería han develado el entendimiento del rol de la dopamina en procesos cognitivos y motores. Los circuitos dopaminérgicos se relacionan principalmente con 3 redes de estado de resposo (RSNs): La ...