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DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers
(Springer New York LLC, 2017)
© 2017, Springer Science+Business Media New York. Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both ...
On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo
(Springer New York LLC, 2017)
© 2017, Springer Science+Business Media New York. Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted ...
Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line
(2011)
Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity
(2012)
We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed ...
Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra
(2002)
The exact mechanism of cell death in neurodegenerative diseases remains obscure, although there is evidence that their pathogenesis may involve the formation of free radicals originating from the oxidative metabolism of ...
Aminochrome induces irreversible mitochondrial dysfunction by inducing autophagy dysfunction in Parkinson's disease
(Frontiers Media S.A., 2018)
Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity
(Springer New York LLC, 2015)
© 2014, Springer Science+Business Media New York.U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases ...
Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: Implications for Parkinson's disease
(2012)
Parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (SN). The underlying neurodegenerative ...
Commentary: Gene therapy: A promising approach for neuroprotection in Parkinson’s disease?
(Frontiers Media S.A., 2017)
Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome
(2000)
Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 μM), a metabolite of the dopamine oxidative pathway, was found ...