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Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
(Springer New York LLC, 2019)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson’s disease. Oxidative stress produces aminochrome ...
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure
(Wiley VCH Verlag, 2017-09)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar ...
DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers
(Springer, 2017)
Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers
(Springer New York LLC, 2017)
© 2017, Springer Science+Business Media New York. Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both ...
DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity
(Oxford University Press, 2015)
It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation.
We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
Structural Insights into Amyloid Oligomers of the Parkinson Disease-related Protein α-Synuclein
(American Society for Biochemistry and Molecular Biology, 2014-09)
The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is attributed to prefibrillar oligomeric ...
Commentary: A humanized clinically calibrated quantitative systems pharmacology model for hypokinetic motor symptoms in Parkinson's disease
(Frontiers Research Foundation, 2016)
Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation
(American Society for Biochemistry and Molecular Biology, 2012-01)
Lewy bodies and Lewy neurites, neuropathological hallmarks of several neurological diseases, are mainly made of filamentous assemblies of α-synuclein. However, other macromolecules including Tau, ubiquitin, glyceraldehyd ...
Structural Characterization of Heparin-induced Glyceraldehyde-3-phosphate Dehydrogenase Protofibrils Preventing α-Synuclein Oligomeric Species Toxicity
(American Society for Biochemistry and Molecular Biology, 2014-03)
Background:Although glycosaminoglycan-induced GAPDH prefibrillar species accelerates -synuclein aggregation, itsrole in toxicity remains unclear.Results:The toxic effect exerted by -synuclein oligomers on cell culture was ...