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Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
(Springer New York LLC, 2019)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson’s disease. Oxidative stress produces aminochrome ...
Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson’s disease
(Taylor and Francis Ltd, 2017)
Copyright © 2016 Informa UK Limited, trading as Taylor & Francis Group.Neuromodulation by spinal cord stimulation has been proposed as a symptomatic treatment for Parkinson’s disease. We tested the chronic effects of spinal ...
Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
(Public Library of Science, 2015-04)
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive ...
DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers
(Springer, 2017)
Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers
(Springer New York LLC, 2017)
© 2017, Springer Science+Business Media New York. Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both ...
Structural Insights into Amyloid Oligomers of the Parkinson Disease-related Protein α-Synuclein
(American Society for Biochemistry and Molecular Biology, 2014-09)
The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is attributed to prefibrillar oligomeric ...
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure
(Wiley VCH Verlag, 2017-09)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar ...
Structural disorder of monomeric α-synuclein persists in mammalian cells
(Nature Publishing Group, 2016-02)
Intracellular aggregation of the human amyloid protein α-synuclein is causally linked to Parkinson's disease. While the isolated protein is intrinsically disordered, its native structure in mammalian cells is not known. ...
Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety
(NATURE PUBLISHING GROUP, 2009)
A genomic region neighboring the alpha-synuclein gene, on rat chromosome 4, has been associated with anxiety- and alcohol-related behaviors in different rat strains. In this study, we have investigated potential molecular ...
Motor deficits and beta oscillations are dissociable in an alpha-synuclein model of Parkinson's disease
(Wiley, 2017)
Parkinson's disease (PD) is a neurodegenerative disorder characterised by progressive motor symptoms resulting from chronic loss of dopaminergic neurons in the nigrostriatal pathway. The over expression of the protein ...