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AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
(Nature Publishing Group, 2017-03)
The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D ...
Brown fat organogenesis and maintenance requires AKT1 and AKT2
(Elsevier Gmbh, 2019-05)
Objective: Understanding the signaling mechanisms that control brown adipose tissue (BAT) development is relevant to understanding energy homeostasis and obesity. The AKT kinases are insulin effectors with critical in vivo ...
Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region
(Public Library of Science, 2020-11)
Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent ...
Angiotensin II Signaling in Human Preadipose Cells: Participation of ERK1,2-Dependent Modulation of Akt
(2013-10)
The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation,
glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic ...
AKT
(Springer, 2018)
AKT is a serine/threonine kinase member of the AGC family of protein kinases. The three isoforms of AKT (AKT1/2/3) play a central role in growth, proliferation, glucose uptake, metabolism, protein translation and cell ...
Study of PI3K/AKT/mTOR pathway in breast cancer progression
(Instituto de Histología y Embriología, 2018)
Deregulation in the PI3K/AKT/mTOR pathway is associated with breast cancer development. Using experimental models of breast carcinogenesis induced in mice, xenografts of tumor cell lines, and tumors from patients we found ...
Modulation of the Akt pathway reveals a novel link with PERK/eIF2alpha, which is relevant during hypoxia
(Public Library Science, 2013-07-29)
The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathways have largely been studied ...
Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression
(Public Library of Science, 2009-10)
Akt is a serine/threonine kinase involved in cell proliferation, apoptosis, and glucose metabolism. Akt is differentially activated by growth factors and oxidative stress by sequential phosphorylation of Ser473 by mTORC2 ...