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PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus
(2019)
In the adult hippocampus new neurons are generated in the dentate gyrus from neural progenitor cells. Adult-born neurons integrate into the hippocampal circuitry and contribute to hippocampal function. PSD95 is a major ...
Requirement of Adult-Born Neurons for Hippocampus-Dependent Learning
(Elsevier Science, 2012-02)
A fundamental question in the field of adult neurogenesis relies in addressing whether neurons generated in the adult dentate gyrus are needed for hippocampal function. Increasing evidence is accumulating in support of the ...
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling
(2020)
In the adult hippocampus, new neurons are generated in the dentate gyrus. The Wnt signaling pathway regulates this process, but little is known about the endogenous Wnt ligands involved. We investigated the role of Wnt5a ...
Adult neurogenesis and the plasticity of the dentate gyrus network
(Wiley Blackwell Publishing, Inc, 2011-03)
The granule cell layer (GCL) of the dentate gyrus contains neurons generated during embryonic, early postnatal and adult life. During adulthood there is a continuous production of neuronal cohorts that develop and functionally ...
Frizzled-1 receptor regulates adult hippocampal neurogenesis.
(2016)
Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt signaling, which plays a ...
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling
(Facultad de Medicina y Ciencia, 2020)
In the adult hippocampus, new neurons are generated in the dentate gyrus. The Wnt signaling pathway regulates this process, but little is known about the endogenous Wnt ligands involved. We investigated the role of Wnt5a ...
A critical period for experience-dependent remodeling of adult-born neuron connectivity
(Cell Press, 2015-02)
Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes ...
GDNF and GFRα1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons
(Elsevier Inc, 2019-12)
The glial cell line-derived neurotrophic factor (GDNF) is required for the survival and differentiation of diverse neuronal populations during nervous system development. Despite the high expression of GDNF and its receptor ...