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A new acridone with antifungal properties against Candida spp. and dermatophytes, and antibiofilm activity against C. albicans
(2019-01-01)
Aim: The increase in the number of fungal infections worldwide, coupled with the limitations of current antifungal chemotherapy, demand the development of safe and effective new antifungals. Here, we presented the synthesis ...
Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4
(2017-07-01)
Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the virus genotype. Acridones, a group of compounds extracted from natural ...
Antiviral activity of an N-allyl acridone against dengue virus
(Biomed Central, 2015-05)
Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are ...
Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses
(International Medical Press, 2008-12)
Background: In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV). Methods: Compounds were tested against Junin virus (JUNV), an ...
Acridone alkaloids as potent inhibitors of cathepsin V
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Cathepsin V is a lysosomal cysteine peptidase highly expressed in thymus, testis and corneal epithelium. Eleven acridone alkaloids were isolated from Swinglea glutinosa (Bl.) Merr. (Rutaceae), with eight of them being ...
Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative
(Elsevier Science, 2012-01)
There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective ...
Oropouche virus in vitro replication is inhibited by acridone
(Amer Soc Trop Med & Hygiene, 2021-11-01)
Acridones As Antiviral Agents: Synthesis, Chemical and Biological Properties
(Bentham Science Publishers, 2013)