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A β-amino acid modified heptapeptide containing a designed recognition element disrupts fibrillization of the amyloid β-peptide
(Wiley, 2010-09)
We study the complex formation of a peptide betaAbetaAKLVFF, previously developed by our group, with Abeta(1-42) in aqueous solution. Circular dichroism spectroscopy is used to probe the interactions between betaAbetaAKLVFF ...
Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
(Elsevier Science Inc, 2009-01)
BACKGROUND: We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) ...
Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic ABeta peptide aggregates
(Public Library of Science, 2013-04-11)
Insulin-degrading enzyme (IDE) is a neutral Zn(2+) peptidase that degrades short peptides based on substrate conformation, size and charge. Some of these substrates, including amyloid â (Aâ) are capable of self-assembling ...
Differential Degradation of Amyloid β Genetic Variants Associated with Hereditary Dementia or Stroke by Insulin-degrading Enzyme
(American Society for Biochemistry and Molecular Biology, 2003-06)
Inherited amino acid substitutions at position 21, 22, or 23 of amyloid beta (Abeta) lead to presenile dementia or stroke. Insulin-degrading enzyme (IDE) can hydrolyze Abeta wild type, yet whether IDE is capable of degrading ...
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.
(Springer/Plenum Publishers, 2000-12)
Insulin degrading enzyme (IDE) is a metalloprotease that has been involved in amyloid beta peptide (A(beta)) degradation in the brain. We analyzed the ability of human brain soluble fraction to degrade A(beta) analogs 1-40, ...
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
(Amer Soc Investigative Pathology, Inc, 2008-08)
Alzheimer's disease (AD) is characterized by the accumulation of extracellular insoluble amyloid, primarily derived from polymerized amyloid-beta (Abeta) peptides. We characterized the chemical composition of the Abeta ...
Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology
(Karger, 2010-04)
Background: Intracellular accumulation of β-amyloid (Aβ) is one of the early features in the neuropathology of Alzheimer's disease (AD) and Down's syndrome. This can be reproduced in cell and transgenic animal models of ...
DETERMINACIÓN DE LAS CONCENTRACIONES DE AMILOIDE β40 Y AMILOIDE β42 EN EL LÍQUIDO AMINIÓTICO DE MUJERES EMBARAZADAS CON FETOS CON TRISOMIA 21
(Facultad de Medicina de la Universidad Central de Venezuela., 2022)
Ponha os pés na água
(Centro de Estudos em Sustentabilidade da EAESP, 2011)
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
(Feinstein Institute for Medical Research, 2008-03)
Presenilin (PS) mutations enhance the production of the Abeta42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Abeta42 species is preferentially produced has not been elucidated, ...