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Targeting Autophagy In Cancer Therapy
(Bentham Science Publishers, 2018)
Macroautophagy is a physiological cellular process that sequesters senescent or damaged organelles and proteins in autophagosomes for recycling of their products. Autophagy is also involved in the removal of cells that ...
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
(Elsevier Ireland Ltd, 2018)
The influence of oxidative stress and autophagy cross regulation on pregnancy outcome
(2016-09-01)
The generation of reactive oxygen species (ROS), a byproduct of aerobic energy metabolism, is maintained at physiological levels by the activity of antioxidant components. Insufficiently opposed ROS results in oxidative ...
Osteoporosis and autophagy: What is the relationship?
(2017-02-01)
Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting ...
Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy
(2021-01-15)
Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-resistance by tumor cells represents a primary obstacle for successful chemotherapy. Autophagy is a physiological mechanism of ...
A new method to measure autophagy flux in the nervous system
(Taylor and Francis Inc., 2014)
A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...
Moderate, but not excessive, training attenuates autophagy machinery in metabolic tissues
(2020-11-02)
The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, ...
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins
(Landes Bioscience, 2015-12)
Autophagy is activated early after human cytomegalovirus (HCMV) infection, but lateron the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 andIRS1, which inhibit autophagy during infection. Expression ...
Autophagy, physiology and cell pathology
(Universidad Nacional de Mar del Plata. Facultad de Medicina. Centro de Investigaciones Cardiovasculares, 2013-12)
Autophagy plays an important role in human pathologies, such as myopathies and neurodegenerative diseases. Moreover, metabolic disease processes such as diabetes and pancreatitis, as well as tumor cells and cancer chemotherapy, ...
Targeting autophagy in neurodegenerative diseases
(Elsevier Ltd, 2014)
© 2014 Elsevier B.V. All rights reserved. The most prevalent neurodegenerative disorders involve protein misfolding and the aggregation of specific proteins. Autophagy is becoming an attractive target to treat neurodegenerative ...