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The connection between splicing and cancer
(Company Of Biologists, 2006)
Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control ...
Alternative splicing and transcription elongation in plants
(Frontiers Media S.A., 2019-03)
Alternative splicing and transcription elongation by RNA polymerase II (RNAPII) are two processes which are tightly connected. Splicing is a co-transcriptional process, and different experimental approaches show that ...
Alternative splicing: a pivotal step between eukaryotic transcription and translation
(Nature Publishing Group, 2013-03)
Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated the prevalence of alternative splicing in multicellular eukaryotes, its key ...
A new portal for the analysis of human splicing variants
(LANDES BIOSCIENCEAUSTIN, 2012)
Understanding alternative splicing is crucial to elucidate the mechanisms behind several biological phenomena, including diseases. The huge amount of expressed sequences available nowadays represents an opportunity and a ...
Differential expression of new LTA splice variants upon lymphocyte activation
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Lymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses. Many TNF superfamily members have functionally ...
Connections between chromatin signatures and splicing
(Wiley, 2013-02)
Splicing and alternative splicing are involved in the expression of most human genes, playing key roles in differentiation, cell cycle progression, and development. Misregulation of splicing is frequently associated to ...
CaMKIId Splice variants in the healthy and diseased heart
(Frontiers Media, 2021)
RNA splicing has been recognized in recent years as a pivotal player in heart
development and disease. The Ca2C/calmodulin dependent protein kinase II delta
(CaMKIId) is a multifunctional Ser/Thr kinase family and generates ...