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Porphyrin synthesis from ALA derivatives for photodynamic therapy: In vitro and in vivo studies
(Nature Publishing Group, 2004-03)
The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as ...
Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: Tissue distribution
(Nature Publishing Group, 2003-02)
Although 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has proven to be clinically beneficial for the treatment of certain cancers, including a variety of skin cancers, optimal tissue localisation still ...
Liberación de delta-ala en orina de niños: un indicador de contaminación por plomo en Santiago
(Sociedad Chilena de Pediatría, 1980)
Fluorescence evaluations for porphyrin formation during topical PDT using ALA and methyl-ALA mixtures in pig skin models
(2016-09-01)
Background Photodynamic Therapy (PDT) using Aminolevulinic acid (ALA) and derivative molecules as topical medication and as a precursor of protoporphyrin (PPIX), is limited due to low permeation through skin or efficiency ...
Osificación de las alas del esfenoides en fetos humanos venezolanos. Sphenoid wings osification in Venezuelan human fetuses.
(Consejo de Desarrollo Científico y Humanístico UCV., 2013)
Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat
(Instituto de la Grasa, 2014)
ALA is the precursor of EPA and DHA and its dietary availability is limited. Vegetable oils rich in
ALA (48–64%) are alternatives for increasing its consumption. The conversion of ALA into EPA and DHA and
the ratio ...
Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy
(Elsevier Science, 2009-04)
The use of endogenous protoporphyrin IX (PpIX) after administration of 5-aminolaevulinic acid (ALA) has led to many applications in photodynamic therapy (PDT). However the efficacy of ALA-PDT is sub-optimal for thicker ...
Sensitivity to ALA-PDT of cell lines with different nitric oxide production and resistance to NO cytotoxicity
(Elsevier Science SA, 2005-09)
In this work, we studied the in vitro interactions between aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) and nitric oxide (NO), as well as the interactions between ALA, porphyrins and some NO donors and ...