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Protección contra el alcoholismo por el polimorfismo ARG47HIS de la deshidrogenasa alcohólica : desarrollo de un modelo animal
(Universidad de ChileCyberDocs, 2009)
El alcoholismo es una de las adicciones de mayor prevalencia en el mundo. Sin
embargo, se ha visto que la presencia de ciertos polimorfismos en los genes de las
enzimas que metabolizan el etanol, son capaces de proteger ...
The reason we drink alcohol is rooted in our evolutionEl porqué de que bebamos alcohol tiene sus raíces en nuestra evolución
(Pontificia Universidad Católica del Perú, 2016)
ADH1B∗2 Is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption
(W B Saunders Co-Elsevier Inc, 2020-05)
Background & Aims: Alcohol dehydrogenase 1B (ADH1B) is involved in alcohol metabolism. The allele A (ADH1B∗2) of the rs1229984: A>G variant in ADH1B is associated with a higher alcohol metabolizing activity compared to the ...
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: Development of an animal model
(2010)
Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it ...
Polimorfismos en el Gen de la deshidrogenasa alcohólica 1C (ADH1C) aumentan el riesgo de alcoholismo en la población chilena
(Universidad de ChilePrograma Cybertesis, 2008)
El riesgo individual de alcoholismo tiene un componente hereditario de 40 a 60%. Los únicos factores genéticos bien establecidos para una susceptibilidad diferenciada al alcoholismo son polimorfismos en los genes de las ...
First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil
(Elsevier B.V., 2017-12-01)
Worldwide, different studies have reported an association of alcohol-use disorder (AUD) with different types of Single Nucleotide Polymorphisms (SNPs) in the genes for aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase ...