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Reversing the peptide sequence impacts on molecular surface behaviour
(Elsevier Science, 2016-03)
The protein's primary structure has all the information for specific protein/peptide folding and, in many cases, can define specific amphiphilic regions along molecules that are important for interaction with membranes. ...
Designing improved active peptides for therapeutic approaches against infectious diseases
(Pergamon-Elsevier Science Ltd, 2018-03)
Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major ...
The effect of acidic residues and amphipathicity on the lytic activities of mastoparan peptides studied by fluorescence and CD spectroscopy
(Springer, 2011-01-01)
Some mastoparan peptides extracted from social wasps display antimicrobial activity and some are hemolytic and cytotoxic. Although the cell specificity of these peptides is complex and poorly understood, it is believed ...
New aspects of the interactions between the cardiovascular nitric oxide system and natriuretic peptides
(Academic Press Inc Elsevier Science, 2011-03)
Arterial blood pressure is regulated by a variety of endocrine, autocrine and neuronal systems. Natriuretic peptides and nitric oxide are important factors that exert synergistic vascular and cardiac actions and their ...
Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
(Elsevier Masson SAS, 2018)
LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats
(Elsevier B.V., 2018-04-01)
Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting ...
The interfacial properties of the peptide Polybia-MP1 and its interaction with DPPC are modulated by lateral electrostatic attractions
(Elsevier Science, 2016-02)
Polybia-MP1 (IDWKKLLDAAKQIL-NH2), extracted from the Brazilian wasp Polybia paulista, exhibits a broad-spectrum bactericidal activity without being hemolytic and cytotoxic. In the present study, we analyzed the surface ...
Design of affinity chromatography peptide ligands through combinatorial peptide libraries screening
(Springer, 2020)
In this chapter, a protocol to design affinity chromatography matrices with short peptide ligands immobilized for protein purification is described. The first step consists of the synthesis of a combinatorial peptide library ...
Adsorption and insertion of polyarginine peptides into membrane pores: the trade-off between electrostatics, acid-base chemistry and pore formation energy
(Academic Press Inc Elsevier Science, 2019-09)
The mechanism that arginine-rich cell penetrating peptides (ARCPPs) use to translocate lipid membranes is not entirely understood. In the present work, we develop a molecular theory that allows to investigate the adsorption ...