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Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation
(Cell Press, 2014-05)
Insight into how amyloid β (Aβ) aggregation occurs in vivo is vital for understanding the molecular pathways that underlie Alzheimer’s disease and requires new techniques that provide detailed kinetic and mechanistic ...
Intrahippocampal Inoculation of Aβ1–42 Peptide in Rat as a Model of Alzheimer’s Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells
(MDPI, 2023)
Circulating microRNAs (miRNAs) have aroused a lot of interest as reliable blood diagnostic biomarkers of Alzheimer's disease (AD). Here, we investigated the panel of expressed blood miRNAs in response to aggregated ...
β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage
(Society for Neuroscience, 2012-05-09)
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains of AD patients and mice models of AD suggested that cholesterol homeostasis is altered in ...
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate Aβ deposition in vivo
(BioMed Central, 2013)
Background: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which
accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral
Aβ-amyloidosis ...
Examining the Ensembles of Amyloid-β Monomer Variants and Their Propensities to Form Fibers Using an Energy Landscape Visualization Method
(2022-01-13)
The amyloid-β (Aβ) monomer, an intrinsically disordered peptide, is produced by the cleavage of the amyloid precursor protein, leading to Aβ-40 and Aβ-42 as major products. These two isoforms generate pathological aggregates, ...
APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
(Elsevier Science Inc, 2018-04-20)
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the ...
Efectos de concentraciones nanomolares del péptido B-amiloide en la actividad sináptica de neuronas hipocampales en cultivo.
(Universidad de Concepción.Facultad de Ciencias BiológicasDepartamento de Biología Celular y Molecular., 2007)
La enfermedad de Alzheimer (EA) se caracteriza por reducción de las funciones cognitivas, la cual se explicaría por un aumento de muerte neuronal. Sin embargo, cambios estructurales en particular reducción de sinapsis son ...
APP signaling in Alzheimer's disease
(Impact Journals, 2018-11)
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter ...
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer
(Academic Press Inc Elsevier Science, 2018-12)
A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as ...