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STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE-HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS
(Elsevier Science BvAmsterdamHolanda, 1995)
Electrochemical Behaviour Study and Determination of Guanine, 6-Thioguanine, Acyclovir and Gancyclovir on Fluorine-doped SnO2 Electrode. Application in Pharmaceutical Preparations
(2017)
An electroanalytical method using square wave voltammetry (SWV) is proposed for the quantification of Guanine (G), 6-Thioguanine (TG), Acyclovir (Acy) and Ganciclovir (Gan) in different types of pharmacological samples. ...
Construction of 6-thioguanine and 6-mercaptopurine carriers based on βcyclodextrins and gold nanoparticles
(Elsevier, 2017)
As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG ...
Construction of 6 - thioguanine and 6 - mercaptopurine carriers based on beta cyclodextrins and gold nanoparticles
(Elsevier, 2017)
As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG ...
Phenotype and genotype of thiopurine methyltransferase in Chilean individuals
(SOC MEDICA SANTIAGO, 2012)
Background: Thiopurines (azathioprine and 6-mercaptopurine) are highly effective medications but with potential adverse effects. Thiopurine methyltransferase (TMPT) is the key enzyme in their pharmacokinetics and is ...
STREPTOZOTOCIN-INDUCED TOXICITY IN CHO-9 AND V79 CELLS
(Wiley-lissNew York, 1995)
Monitoração terapêutica da azatioprina: uma revisão
(Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2008)
Os nucleotídeos de tioguanina (6-TGN), metabólitos ativos da azatioprina (AZA) e da 6-mercaptopurina (6-MP), atuam como antagonistas das purinas, inibindo as sínteses de DNA, RNA e a protéica, e induzindo à citotoxicidad ...
Mutagenic consequences of the incorporation of 6-thioguanine into DNA
(1997)
6-Thioguanine (S6G) has been used in the treatment of acute leukemias because of its cytotoxic effect on proliferating leukemic cells. The cytotoxicity of S6G is thought to derive from its incorporation into DNA in place ...