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Efeito da administração local ou sistêmica do Lactobacillus reuteri, no tratamento da doença periodontal experimentalmente induzida em ratos, submetidos à quimioterapia com 5-fluorouracil: estudo histopatológico, histométrico e imunoistoquímico
(Universidade Estadual Paulista (Unesp), 2018-10-19)
Os probióticos (PROs) estão sendo intensamente avaliados na prevenção ou tratamento de doenças da cavidade oral, que estão associadas a uma mudança na composição e atividade microbiana do biofilme e resposta do hospedeiro. ...
Durable Complete Responses in Metastatic Colorectal Cancer Treated with Chemotherapy Alone
(CIG MEDIA GROUP, LP, 2011)
Background/Purpose: The median survival for patients with metastatic colorectal cancer (mCRC) has progressively increased over the past decades. Since the introduction of 5-fluorouracil (5-FU)-based chemotherapy, followed ...
Mucosite oral induzida em ratos wistar tratados com atorvastatina -determinação do potencial preventivo, número de leucócitos e processo de caquexia.
(Universidade Federal de Juiz de Fora (UFJF)BrasilFaculdade de MedicinaPrograma de Pós-graduação em Saúde BrasileiraUFJF, 2020)
Monitoramento terapêutico do 5-fluorouracil como ferramenta clínica de avaliação no tratamento de pacientes com câncer do trato gastrointestinal
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2023-07-21)
5-fluorouracil (5-FU) is an essential part of the treatment of numerous solid cancers, especially
of the gastrointestinal tract (GI tract). Despite the many advances related to its use, some
patients undergoing 5-FU ...
Low Concentration of 5-Fluorouracil Increases the Effectiveness of Tumor RNA to Activate Murine Dendritic Cells
(Mary Ann Liebert, Inc, 2017-10-01)
Aim: Considering the central role of dendritic cells (DCs) on the development of an antitumor immune response, in this study we used a murine model to evaluate how DC transfection with drug-treated tumor cell RNA changes ...
Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells
(Wiley, 2010-06)
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related death worldwide. Current treatments are extremely disappointing. SPARC (Secreted protein, acidic and rich in ...
Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro
(Springer, 2013-05)
Purpose: Acquired multidrug resistance (MDR) has been linked to overexpression of drug-metabolising and transporting proteins mediated by pregnane-x-receptor (PXR). The aim of this work was to establish the relevance of ...
Correlation Between Thymidylate Synthase Protein Expression and Gene Polymorphism With Clinicopathological Parameters in Colorectal Carcinoma
(Sage Publications IncThousand OaksEUA, 2009)
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer
(2021)
Background: Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe ...
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer
(2021)
Background: Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe ...