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Protein palmitoylation inhibition by 2-bromopalmitate alters gliding, host cell invasion and parasite morphology in Toxoplasma gondii
(Elsevier Science, 2012-07)
Protein palmitoylation is the reversible covalent attachment of palmitic acid onto proteins. This post-translational modification has been shown to play a part in diverse processes such as signal transduction, cellular ...
2-Bromopalmitate Reduces Protein Deacylation by Inhibition of Acyl-Protein Thioesterase Enzymatic Activities
(Public Library Science, 2013-10)
S-acylation, the covalent attachment of palmitate and other fatty acids on cysteine residues, is a reversible post-translational modification that exerts diverse effects on protein functions. S-acylation is catalyzed by ...
Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells
(WILEY-LISS, 2008)
The effect of unbound palmitic acid (PA) at plasma physiological concentration range on reactive oxygen species (ROS) production by cultured rat skeletal muscle cells was investigated. The participation of the main sites ...
Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation
(Portland Press, 2017-08)
Ganglioside glycosyltransferases (GGTs) are type II membrane proteins bearing a short N-terminal cytoplasmic tail, a transmembrane domain (TMD), and a lumenal catalytic domain. The expression and activity of these enzymes ...
Protein palmitoylation plays an important role in Trichomonas vaginalis adherence
(American Society for Biochemistry and Molecular Biology, 2018-11)
The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide. As an obligate extracellular pathogen, adherence to ...
Estudos sobre a S-palmitoilação de proteínas em Trypanosoma cruzi
(Fundação Oswaldo Cruz. Instituto Carlos Chagas., 2019)