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Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease
(NLM (Medline), 2020)
Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction
(2019)
Mechanical force transmission through the adherens junctions (AJs) are highly regulated processes essential for multicellular organization of tissues. AJ proteins such as E-cadherin, α-catenin, and vinculin have been shown ...
cdk5 modulates β- and δ-catenin/Pin1 interactions in neuronal cells
(2007)
The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have ...
β-catenin expression during the canine epidermal development
(Latin American Society for Developmental Biology, 2019)
β-catenin plays a central role both in the adherent intercellular junctions, as well as in the canonical Wnt signalling pathway. The study of the expression pattern of this protein during the canine epidermal development ...
P-Cadherin and β-catenin are useful prognostic markers in breast cancer patients; β-catenin interacts with heat shock protein Hsp27
(Springer, 2008-06)
The cadherin-catenin proteins have in common with heat shock proteins (HSP) the capacity to bind/interact proteins of other classes. Moreover, there are common molecular pathways that connect the HSP response and the ...
β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation
(Academic Press Inc., 2019)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The ...
The first armadillo repeat is involved in the recognition and regulation of β-catenin phosphorylation by protein kinase CK1
(2006)
Multiple phosphorylation of β-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic peptides encompassing ...
Transactivation activity and nucleocytoplasmic transport of β-catenin are independently regulated by its C-terminal end
(Elsevier, 2015)
The key protein in the canonicalWnt pathway is β-catenin, which is phosphorylated both in absence and presence
ofWnt signals by different kinases. Upon activation in the cytoplasm, β-catenin can enter into the nucleus ...
Nuclear localization of β-catenin and expression of target genes are associated with increased Wnt secretion in oral dysplasia
(Elsevier, 2019)
Objectives: To evaluate the localization of β-catenin in oral dysplastic cells, the expression of target genes upregulated
in oral dysplasia, and the role of Wnt ligands in these events.
Materials and methods: Subcellular ...
In vitro studies revealed a downregulation of Wnt/β-catenin cascade by active vitamin D and TX 527 analog in a Kaposi's sarcoma cellular model
(Pergamon-Elsevier Science Ltd, 2020-03)
The Kaposi´s sarcoma-associated herpesvirus G-protein-coupled receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi´s sarcoma. We have previously demonstrated that 1α,25(OH)2D3 or its less calcemic analogTX 527 ...