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The future of the β-lactams
(Current Biology, 2010-10)
In the 80 years since their discovery the β-lactam antibiotics have progressed through structural generations, each in response to the progressive evolution of bacterial resistance mechanisms. The generational progression ...
An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in β-lactam resistance
(Nature Research, 2019-12)
The treatment of hospital- and community-associated infections by methicillin-resistant Staphylococcus aureus (MRSA) is a perpetual challenge. This Gram-positive bacterium is resistant specifically to β-lactam antibiotics, ...
Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum beta-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru
(MDPI, 2021)
Urinary tract infections (UTIs) are a common human infection. Antibiotic resistance in extended-spectrum beta-lactamase (ESBL)-producing uropathogenic E. coli (UPEC) is a major therapeutic challenge due to limited treatment ...
How Allosteric Control of Staphylococcus aureus Penicillin-Binding Protein 2a Enables Methicillin-Resistance and Physiological Function
(National Academy of Sciences, 2013-10)
The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical resistance to the β-lactam antibiotics by methicillin-resistant Staphylococcus aureus (MRSA). The highmolecular mass penicillin ...
Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase
(Nature Publishing Group, 2016-07)
Carbapenems, 'last-resort' β-lactam antibiotics, are inactivated by zinc-dependent metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal ions from microbial pathogens by releasing metal-chelating ...
Beta-lactam resistance in enterobacteria isolated from animal and water
(Universidad Nacional del Nordeste, 2016)
β-lactam and tetracycline residues in fresh milk acquired by the Glass of Milk Committees of the San Jerónimo and Andahuaylas districts in Apurímac, PeruResiduos β-lactámicos y tetraciclinas en la leche fresca adquirida por Comités de Vaso de Leche de los distritos de San Jerónimo y Andahuaylas, Apurímac, Perú
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, 2020)
Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase
(American Chemical Society, 2016-01)
Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major public health threat. Zn(II)-dependent or metallo-β-lactamases (MBLs) produced by these bacteria inactivate most β-lactam antibiotics, ...