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β-lactam antibiotics epitope mapping with STD NMR spectroscopy: A study of drug-human serum albumin interaction
(2012-04-02)
Molecular recognition events are key issues in many biological processes. STD NMR (saturation transfer difference nuclear magnetic resonance spectroscopy) is one of the techniques used to understand such biological ...
Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064
(Brazilian Archives of Biology and Technology, 2012-12-01)
The aim of this work was to compare the composition of a complex and soluble culture medium to eight other media described in the literature through the batch cultivation in a conventional bench-scale bioreactor for the ...
Short communication: β-Lactam resistance and vancomycin heteroresistance in Staphylococcus spp. isolated from bovine subclinical mastitis
(2017-08-01)
The use of antimicrobial agents has led to the emergence of resistant bacterial strains over a relatively short period. Furthermore, Staphylococcus spp. can produce β-lactamase, which explains the survival of these strains ...
Micellar catalysis of the intramolecular aminolysis of the β‐lactam antibiotic cephaclor
(1991-01-01)
The rate of intramolecular degradation of cephaclor, involving the attack of the amino group at C‐17 (N‐18) on the β‐lactam carbonyl, was increased up to 50‐fold by neutral (polyoxyethylene‐23 lauryl ether; Brij) and ...
Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA)
(American Chemical Society, 2014-02)
β-Lactam antibiotics have faced obsolescence with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). A complex set of events ensues upon exposure of MRSA to these antibiotics, which culminates in proteolysis ...
Resistance to tetracycline and β-lactams and distribution of resistance markers in enteric microorganisms and pseudomonads isolated from the oral cavity
(Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru, 2009-12-01)
This study evaluated the occurrence of enteric bacteria and pseudomonads resistant to tetracycline and beta-lactams in the oral cavity of patients exhibiting gingivitis (n=89); periodontitis (n=79), periodontally healthy ...