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α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
(Nature Publishing Group, 2018-08)
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson´s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation ...
Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment
(Elsevier Science Inc, 2018-08)
α-synuclein is involved in both familial and sporadic Parkinson's disease. Although its interaction with mitochondria has been well documented, several aspects remains unknown or under debate such as the specific ...
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure
(Wiley VCH Verlag, 2017-09)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar ...
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
(Academic Press Inc Elsevier Science, 2018-04)
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the ...
Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
(Blackwell Publishing Ltd, 2015)
© 2015 International Society for Neurochemistry. It has been postulated that the accumulation of extracellular α-synuclein (α-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to ...
Structural disorder of monomeric α-synuclein persists in mammalian cells
(Nature Publishing Group, 2016-02)
Intracellular aggregation of the human amyloid protein α-synuclein is causally linked to Parkinson's disease. While the isolated protein is intrinsically disordered, its native structure in mammalian cells is not known. ...
A new model to study cell-to-cell transfer of αSynuclein in vivo
(Elsevier B.V., 2018)
© 2018 Elsevier Inc. Parkinson's disease (PD) compromises motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the histopathological level, PD is characterized by the accumulation ...
Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations
(Royal Society of Chemistry, 2016-01)
We perform here enhanced sampling simulations of N-terminally acetylated human α-synuclein, an intrinsically disordered protein involved in Parkinson's disease. The calculations, consistent with experiments, suggest that ...