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Membrane depolarization induces calcium-dependent upregulation of Hsp70 and Hmox-1 in skeletal muscle cells
(2009)
Heat shock proteins (HSPs) are a conserved family of cytoprotective polypeptides, synthesized by cells in response to stress. Hsp70 and heme oxygenase 1 (Hmox-1) are induced by a variety of cellular stressors in skeletal ...
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor
(Wiley, 2020)
Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
Calcium microdomains and gene expression in neurons and skeletal muscle cells
(CHURCHILL LIVINGSTONE, 2006-12)
Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting ...
Mechanical disturbance of osteoclasts induces atp release that leads to protein synthesis in skeletal muscle through an akt-mtor signaling pathway
(MDPI, 2022)
Muscle and bone are tightly integrated through mechanical and biochemical signals.
Osteoclasts are cells mostly related to pathological bone loss; however, they also start physiological
bone remodeling. Therefore, ...
Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
(Elsevier, 2020)
The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...
Ion pathways in transverse tubules. Quantification of receptors in membranes isolated from frog and rabbit skeletal muscle
(Elsevier, 1986)
The presence of four cation pathways in membrane vesicles isolated from transverse tubules of frog and
rabbit skeletal muscle was studied by measuring binding of specific blockers. Transverse tubules purified
from frog ...
Proteome Profiling and Ultrastructural Characterization of the Human RCMH Cell Line: Myoblastic Properties and Suitability for Myopathological Studies
(AMER CHEMICAL SOC., 2016)
Studying (neuro)muscular disorders is a major topic in biomedicine with a demand for suitable model systems. Continuous cell culture (in vitro) systems have several technical advantages over in vivo systems and became ...
Angiotensin (1-7) decreases myostatin-induced NF-kappa B signaling and skeletal muscle atrophy
(MDPI, 2020)
Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
Beta-Actin shows limited mobility and is required only for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle
(American Physiological Society, 2018)
Studies in skeletal muscle cell cultures suggest that the cortical actin cytoskeleton is a major requirement for insulin-stimulated glucose transport, implicating the beta-actin isoform, which in many cell types is the ...
Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads
(2002)
Annexin VI is a 68-kDa protein of the Annexin family, a group of Ca2+-dependent phospholipid-binding proteins widely distributed in mammalian tissues including skeletal muscle. We investigated a) which membrane system ...