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Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
(Impact Journals LLC, 2015)
The evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed at higher levels in obese women and stimulates cell migration in other epithelial cancers. Here, we explored the clinical impact ...
Association between feeding behavior, and genetic polymorphism of leptin and its receptor in obese chilean children Asociación entre la conducta alimentaria y polimorfismos genéticos de la leptina y su receptor en niños obesos chilenos
(Grupo Aula Medica S.A., 2015)
© 2015, Grupo Aula Medica S.A. All rights reserved. Introduction: Leptin (LEP) is mainly produced in adipose tissue and acts in the hypothalamus to regulate energy intake. Mutations in the LEP gene or its receptor (LEPR) ...
Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) is characterized by impaired leptin action
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-03-01)
The bone marrow contains mesenchymal stem cells (MSCs) that differentiate to the osteogenic and adipogenic lineages. The fact that the decrease in bone volume of age-related osteoporosis is accompanied by an increase in ...
Perfil fisiológico de la leptina.
(2013-11-01)
Introducción: La leptina fue descubierta en el contexto de sus efectos sobre el control de la alimentación
y del gasto energético. Aunque en un principio se pensó que la leptina actuaba sólo sobre ciertos centros
hipotalámicos, ...
The obese child in the Intensive Care Unit. Update
(Soc. Argentina Pediatria, 2016)
Given that childhood obesity is an epidemic, the frequency of critically-ill patients who are overweight or obese seen at intensive care units has increased rapidly. Adipose tissue is an endocrine organ that secretes a ...
Effects of treatment with leptin-like peptides on factors related to body fat control in Wistar rats fed a high-fat diet.
(2011-11-10)
Introduction: The results of administering recombinant leptin, as well as the 116-130 peptide of mouse leptin in ob/ob
mice have shown the probability of discovering more efficient leptin-based therapeutic methods to treat ...
The role of leptin/adiponectin ratio in metabolic syndrome and diabetes
(2014-04-18)
The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and
adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association ...
Adipokines underlie the early origins of obesity and associated metabolic comorbidities in the offspring of women with pregestational obesity
(Elsevier, 2020)
Maternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal ...