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Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
(1998-10-01)
Maternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth ...
Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
(Elsevier B.V., 1995-12-27)
The presence of tyrosine-phosphorylated proteins was studied in cultured rat pancreatic islets, Immunoblotting performed with total extracts of islets cultured in the presence of 1.8 or 5.6 mM glucose revealed at least ...
Effects of fluoride intake on insulin sensitivity and insulin signal transduction
(Int Soc Fluoride Research, 2008-10-01)
Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered ...
Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
(1997-03-01)
Malnutrition is related to diabetes in tropical countries. In experimental animals, protein deficiency may affect insulin secretion. However, the effect of malnutrition on insulin receptor phosphorylation and further ...
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
(Int Soc Fluoride Research, 2010-01-01)
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated ...
Low ethanol consumption induces enhancement of insulin sensitivity in liver of normal rats
(2005-08-26)
Moderate amounts of alcohol intake have been reported to have a protective effect on the cardiovascular system and this may involve enhanced insulin sensitivity. We established an animal model of increased insulin sensitivity ...
Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats
(2013-02-25)
It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and ...
Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid
(Soc Biolgia Chile, 2011-01-01)
Chronic administration of glucocorticoids induces insulin resistance that is compensated by an increase in beta-cell function and mass. Since insulin signaling is involved in the control of beta-cell function and mass, we ...
NaF treatment increases TNF-alpha and resistin concentrations and reduces insulin signal in rats
(Elsevier B.V. Sa, 2012-04-01)
The use of fluoridated products has significantly contributed to the reduction in rates of dental caries. However, excessive sodium fluoride (NaF) intake promotes inhibition of glycolysis, decrease in insulin secretion, ...
Periodontal Disease Decreases Insulin Sensitivity and Insulin Signaling
(Amer Acad Periodontology, 2012-07-01)
Background: The purpose of this study is to investigate whether local inflammatory events, such as periodontal disease, are able to increase tumor necrosis factor-alpha (TNF-alpha) plasmatic concentration and decrease ...