Now showing items 1-10 of 2679
Estudos sobre liberação controlada e vetorização de drogas através de lipossomas
The text highlights the state of research related with the application of liposomes in the control of drug delivery and drug target to infectious diseases. Liposomes have several pharmaceutical applications and this ...
Constituintes de Sorocea bomplandii Baillon
The chemical investigation of the leaves of Sorocea bomplandii Baillon (Moraceae) led to the identification of pentacyclic triterpenes, fatty acid ester and isoprenoids. Chromatographyc comparison between the infusion S. ...
Estudos de medicamentos biosimilares
In Brazil, the registration of new drugs is carried out only when the regulatory agency (Anvisa, acronym in Portuguese) is fully satisfied with the evidence of their quality, efficacy and safety, presented by a pharmaceutical ...
Clinical management of drug-resistant tuberculosis in resource constrained settings
(Sage Publications, 2013-06)
Drug-resistant forms of tuberculosis (TB), particularly multi- and extensively drug-resistant TB, represent an important obstacle to global control of the disease. Recently, new drugs, repurposed drugs, and new drug ...
Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
(Sociedad Médica de Santiago, 2001)
Antitubercular drug discovery: the molecular modification as promise tool
Tuberculosis is a chronic infectious disease caused by etiologic agent Mycobacterium tuberculosis. "It has been reported that rates of incidence is increasing and each year around 8.9-9.9 million new cases are detected”. ...
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
Estudo de perfil de dissolução dos medicamentos de referência, genérico e similar contendo cefalexina na forma farmacêutica cápsula
With recent advances in technology and research into drug delivery, the modernization of tests and greater emphasis on the predictability of therapeutic effect by means of in vitro tests, the dissolution test and the study ...
Modern drug discovery technologies: opportunities and challenges in lead discovery
(Bentham ScienceBussum, 2011-12)
The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have ...