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Mostrando ítems 1-10 de 58
Cytogenetic evaluation of 20 primary breast carcinomas
(1997-11-03)
Chromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. ...
Different responses to doxorubicin-induced chromosome aberrations in Brazilian deer species
(Funpec-editora, 2010-01-01)
The tendency toward chromosome fragility is one of the theories that may explain chromosome variation in brocket deer species (genus Mazama). We tested doxorubicin as an inducer of chromosome aberrations in lymphocytes of ...
Chromosome aberrations as a predictor of clinical outcome for smoking associated lung cancer
(Elsevier B.V., 2000-09-29)
The ability to identify individuals at greatest risk of developing lung cancer can significantly enhance the efficacy of intervention modalities. One strategy for identifying these individuals is through biomarkers that ...
Chromosome damage induced by 5-azacytidine under the influence of caffeine or cytosine arabinoside in CHO-K1 (wild-type) and XRS-5 (mutant) cell lines
(2001-07-14)
5-azacytidine (5-azaC) treatment combined with cytosine arabinoside (ara-C) or caffeine were performed in vitro in Chinese hamster cells, CHO-K1 (wild-type) and xrs-5 (mutant) cell lines, in order to compare the cell ...
Micronucleus and chromosome aberrations induced in onion (Allium cepa) by a petroleum refinery effluent and by river water that receives this effluent
(Academic Press Inc. Elsevier B.V., 2009-11-01)
In this study, micronucleus (MN) and chromosome aberration (CA) tests in Allium cepa (onion) were carried out in order to make a preliminary characterization of the water quality of the Atibaia River in an area that is ...
Genotoxicity of Brosimum gaudichaudii measured by the Salmonella/microsome assay and chromosomal aberrations in CHO cells
(Elsevier B.V., 2002-07-01)
The root bark of Brosimum gaudichaudii Trecul (Moraceae) is popularly used for treatment of vitiligo. In the present study the mutagenic activity of the aqueous and methanolic extract as well as of the n-butanolic fraction ...
Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas
(Sociedade Brasileira de Genética, 2003-01-01)
Head and neck carcinomas represent the sixth most frequent type of cancer in the world, and 90% are derived from squamous cells (HNSCC). In this study of 15 HNSCC cases, extensive aneuploidy was detected by G banding in ...
Chromosomal aberrations induced by 5-azacytidine combined with VP-16 (etoposide) in CHO-K1 and XRS-5 cell lines
(Wiley-Blackwell, 2003-01-01)
A cytogenetic study was carried out with 5-azacytidine (5-azaC) and etoposide (VP-16) in CHO-K1 and XRS-5 (mutant cells deficient for double-strand break rejoining) cell lines to verify the interaction effects of the drugs ...
Comparative effects of acute and subacute lycopene administration on chromosomal aberrations induced by cisplatin in male rats
(Elsevier B.V., 2006-08-01)
Lycopene is a natural carotenoid, free radical scavenger, and presents protective effects by inhibiting oxidative DNA damage. The objective of the current study was to investigate the cytogenetic effects of a single acute ...
Predisposing genes and increased chromosome aberrations in lung cancer cigarette smokers
(Elsevier B.V., 1997-09-05)
Genotoxic effects linking cigarette smoking with lung cancer have not been consistently demonstrated, therefore claims for the cause-effect relationships are vigorously contested. Using matched populations of 22 lung cancer ...