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Drosophila p115 is required for Cdk1 activation and G2/M cell cycle transition
(Elsevier, 2017-04)
Golgi complex inheritance and its relationship with the cell cycle are central in cell biology. Golgi matrix proteins,
known as golgins, are one of the components that underlie the shape and functionality of this organelle. ...
Cell cycle genes are activated earlier than respiratory genes during release of grapevine buds from endodormancy
(Taylor & Francis, 2017)
Single-bud cuttings of Vitis vinifera L exposed to forced growing conditions were used to investigate the involvement of phytohormones, abscisic acid (ABA), auxin (Aux) and cytokinin (CK) in the release of buds from the ...
Xiro homeoproteins coordinate cell cycle exit and primary neuron formation by upregulating neuronal-fate repressors and downregulating the cell-cycle inhibitor XGadd45-γ
(2002)
The iroquois (iro) homeobox genes participate in many developmental processes both in vertebrates and invertebrates, among them are
neural plate formation and neural patterning. In this work, we study in detail Xenopus ...
Cell cycle and protein complex dynamics in discovering signaling pathways
(World Scientific Publishing Co. Pte Ltd, 2019)
Signaling pathways are responsible for the regulation of cell processes, such as monitoring the external environment, transmitting information across membranes, and making cell fate decisions. Given the increasing amount ...
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes
(Wiley, 2018-06)
SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated ...
Determinants of anti-cancer effect of mitochondrial electron transport chain inhibitors: Bioenergetic profile and metabolic flexibility of cancer cells
(Bentham Science Publishers B.V., 2016)
© 2016 Bentham Science Publishers. Recent evidence highlights that energy requirements of cancer cells vary greatly from normal cells and they exhibit different metabolic phenotypes with variable participation of both ...
Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2
(2004)
The protein kinase CK2 is constituted by two catalytic (α and/or α′) and two regulatory (β) subunits. CK2 phosphorylates more than 300 proteins with important functions in the cell cycle. This study has looked at the ...
InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer
(Taylor & Francis, 2016-06)
Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP3R-mediated Ca2+ transfer to mitochondria as an unexpected requirement for ...
Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells
(SAGE Publications Inc., 2018)
© The Author(s), 2018. Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it ...
Enhanced anti-cancer activity of chitosan loaded Morinda citrifolia essential oil against A549 human lung cancer cells
(Elsevier, 2020)
In the present study, the chemical composition of Morinda citrifolia essential oils was determined by gas chromatography-mass spectrometry and was found to contain several anti-cancer compounds including L-scopoletin, ...