Now showing items 1-10 of 10
Absolute bioavailability determination of a sustained release theophylline DETERMINACION DE LA BIODISPONIBILIDAD ABSOLUTA DE UN COMPRIMIDO DE LIBERACION CONTROLADA DE TEOFILINA
The absolute biovailability of a sustained release tablet developed in our laboratory was evaluated. The formulation employs acrylic resins Eudragit as the sustaining release system and tablets were obtained using conventional ...
Plasma concentrations of disulfiram after injection of suspended micropellets into alcoholic subjects
The disposition of disulfiram after administration in a new formulation was studied in rats and alcoholic patients. The suspension consisted of microcrystals suspended in a mixture of propylene glycol and water and injected ...
In vitro conditions for the study of the in vivo performance of sustained-release theophylline matrix tablets administered in fasted conditions and with a high-fat diet
(Marcel Dekker Inc., 1999)
Dissolution profiles of theophylline (TP) from three types of sustained- release (SR) matrix tablets (plastic [PL], lipid [LP], and hydrophilic [HP]) in different dissolution media, with and without enzymes, were established. ...
Evaluation of the in vitro and in vivo performance of two sustained- release lithium carbonate matrix tablets. Effect of different diets on the bioavailability
Two sustained-release (SR) lithium carbonate (Li) matrix tablets, which use a hydrophilic (HP) matrix of hydroxypropylmethylcellulose (Methocel 4K MP) and a lipid (L) matrix of hydrogenated castor oil (Cutina HR) as ...
Development of novel EE/Alginate polyelectrolyte complex nanoparticles for lysozyme delivery: Physicochemical properties and in vitro safety
(MDPI AG, 2019)
The number of biologic drugs has increased in the pharmaceutical industry due to their high therapeutic efficacy and selectivity. As such, safe and biocompatible delivery systems to improve their stability and efficacy are ...
Rational development of a novel hydrogel as a pH-sensitive controlled release system for nifedipine
(MDPI AG, 2018)
© 2018 by the authors. This work depicts the rational development (in-silico design, synthesis, characterization and in-vitro evaluation) of polyvinyl alcohol hydrogels (PVAH) cross-linked with maleic acid (MA) and linked ...
The bioavailability of 4 sustained-release theophylline preparations from the Chilean market Biodisponibilidad de cuatro preparados de teofilina de liberación sostenida del mercado nacional.
We evaluated pharmacokinetic parameters and bioavailability of 4 sustained release theophylline preparations. A crossover design was used in 12 healthy males aged 22 to 27 years old. Each individual received 250 mg iv ...
Preparation of a novel lipid-core micelle using a low-energy emulsification method
(Springer Verlag, 2018)
High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics ...
Rational design, synthesis and evaluation of γ-CD-containing cross-linked polyvinyl alcohol hydrogel as a prednisone delivery platform
(MDPI AG, 2018)
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as ...
En búsqueda de una alternativa de manejo del camanduleo de la papa ocasionada por Spongospora subterraneaSearching for an alternative to manage powdery scab, caused by Spongospora subterranea, in potato
(Universidad Pedagógica y Tecnológica de Colombia, 2019)