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Skeletal Muscle Necrosis and Regeneration after Injection of BaH1, A Hemorrhagic Metalloproteinase Isolated from the Venom of the Snake Bothrops asper (Terciopelo)

Gutiérrez, José María; Romero, Marjorie; Núñez, Javier; Chaves Mora, Fernando; Borkow, Gadi; Ovadia, Michael (1995-02)

The effects of BaH1, a hemorrhagic metalloproteinase isolated from Bothrops asper venom, on mouse gastrocnemius muscle was investigated. The toxin induced severe hemorrhage within minutes after injection. Groups of necrotic ...

Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture

Saravia Otten, Patricia; Robledo, Bárbara; Escalante Muñoz, Teresa; Bonilla, Llira; Rucavado Romero, Alexandra; Lomonte, Bruno; Hernández, Rosario; Flock, Jan-Ingmar; Gutiérrez, José María; Gastaldello, Stefano (2013-02)

Introduction: Viperid snakebite envenomings are characterized by muscle necrosis and a deficient regenerative response. Methods: Homogenates from gastrocnemius muscles of mice injected with the venom of the snake Bothrops ...

Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle

Ownby, Charlotte L.; Odell, George V.; Gutiérrez, José María (1984)

A myotoxic phospholipase has been isolated from Bothrops asper venom by ion-exchange chromatography on CM-Sephadex followed by gel filtration on Sephadex G-75. The toxin is a basic polypeptide with an estimated molecular ...

Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves

Hernández, Rosario; Cabalceta, Carmen; Saravia Otten, Patricia; Chaves, Alessandra; Gutiérrez, José María; Rucavado Romero, Alexandra (PLoS ONE 6(5): e19834, 2011-05-24)

Background: Viperid snakebite envenoming is characterized by prominent local tissue damage, including muscle necrosis. A frequent outcome of such local pathology is deficient skeletal muscle regeneration, which causes ...

Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study.

Arce, Vilma; Brenes Pino, Fernando; Gutiérrez, José María (1991)

The degenerative and regenerative changes in murine skeletal muscle after injection of Bothrops asper venom were studied by histological, lectin histochemical and immunocytochemical techniques. According to our observations, ...

Immunohistochemical demonstration of the binding of bothrops asper myotoxin to skeletal muscle sarcolemma

Brenes Pino, Fernando; Gutiérrez, José María; Lomonte, Bruno (1987)

The binding of Bothrops asper myotoxin to mouse skeletal muscle was studied at both the light and electron microscope levels using the peroxidase anti-peroxidase technique. The toxin binds to muscle cell sarcolemma, and ...

Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom

Gutiérrez, José María; Chaves Mora, Fernando; Cerdas Fallas, Luis (1986)

The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied. The venom induced myonecrosis, and a prominent decrease in muscle levels of creatine kinase ...

Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity

Gutiérrez, José María; Ownby, Charlotte L. (2003-12)

Local and systemic skeletal muscle degeneration is a common consequence of envenomations due to snakebites and mass bee attacks. Phospholipases A2 (PLA2) are important myotoxic components in these venoms, inducing a similar ...

Skeletal muscle regeneration after myonecrosis induced by crude venom and a myotoxin from the snake Bothrops asper (Fer-de-Lance).